The NFL season continues in Week 15 when the San Francisco 49ers host the Tennessee Titans on Sunday. Start time, how to watch, stream and NFL TV schedule.

NFL Week 16 odds, picks, predictions, TV channel, streaming information for Monday Night Football between San Francisco 49ers and Indianapolis Colts.

San Francisco 49ers wide receiver Ricky Pearsall is dealing with multiple injury concerns following Week 15’s win vs. the Titans.

The 49ers are just one game back of the NFC-leading Los Angeles Rams (11-3) for the conference’s No. 1 playoff seed, but Los Angeles plays the Seattle Seahawks — also 11-3 — in Week 16, so San Francisco won’t be able to claim the top seed in Week 16 since one of those two teams still will have a better record at the end of the week.

The San Francisco 49ers will look to continue their push for the NFL playoffs when they host the Tennessee Titans on Sunday. San Francisco (9-4) is hot on the tails of the Los Angeles Rams and Seattle Seahawks in the NFC West, while Tennessee (2-11) is in contention to earn the first overall pick in next year's NFL Draft.

Things are looking good in terms of injuries for the 49ers coming out of a 37-24 win over the Tennessee Titans, but the status of wide receiver Ricky Pearsall Jr. won’t be known until later

Just 24 hours before their Week 15 matchup vs. the Tennessee Titans, the San Francisco 49ers got a concerning update on Christian McCaffrey.

The Indianapolis Colts (8-5) travel to the Pacific Northwest to take on the Seattle Seahawks (10-3)(-13.5) to try to keep their late season playoff hopes alive. This Sunday’s late afternoon game kicks off at 4:25 PM EST.