The human glycosylase OGG1 extrudes and excises the oxidized DNA base 8-oxoguanine (8-oxoG) to initiate base excision repair and plays important roles in many pathological conditions such as cancer, ...

A triple helical DNA can control gene expression, help in homologous recombination, induce mutations to facilitate DNA repair mechanisms, suppress oncogene formations, etc. However, the structure and ...

Diagrams: Short section of DNA, 1951 -- Chemical structures of the DNA bases, 1951 -- Covalent bonds of the sugar-phosphate backbone -- Schematic view of a nucleotide -- Mg** ions binding phosphate ...

Left panels: Atomic Force Microscopy images show how circular DNA can shift from a relaxed shape into a tightly twisted form, and how the gene-editing protein Cas9 binds to this coiled DNA (Credit: ...

They were hardly modest, these two brash young scientists who in 1953 declared to patrons of the Eagle Pub in Cambridge, England, that they had "found the secret of life." But James Watson and Francis ...

DNA (deoxyribonucleic acid), the molecular "blueprint" carrying the genetic instructions that influence the growth, development, reproduction and predispositions of individual humans, can undergo ...

Scientists uncovered DNA's double helix structure in 1953. James Watson and Francis Crick proposed the model. It explained ...

A collaborative study by the UTokyo-KI LINK program, headed by Camilla Björkegren from Karolinska Institutet, Kristian Jeppsson and Katsuhiko Shirahige from The University of Tokyo shows that a ...

MSK researchers are shedding new light on G-quadruplexes, a type of secondary DNA structure that can cause DNA replication to stall. The structures are a potential therapeutic target in cancer. Image ...

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...