Alternative splicing (AS) plays an essential role in development, differentiation and carcinogenesis. However, the mechanisms underlying splicing regulation during mouse embryo gastrulation remain ...

Research from Ph.D. candidate Bohan Chen in the lab of Idse Heemskerk of the Department of Cell and Developmental Biology at the University of Michigan Medical School and their colleagues improves ...

When planning a trip, it's rare that you don't have a choice of route. One may be more direct, another more scenic; but regardless of the time or route taken, the destination is the same. This concept ...

Using a new approach for studying live embryonic mouse brains at single-cell resolution, researchers have identified an active multi-layer circuit that forms in the cortex during an unexpectedly early ...

Recent discoveries in stem cell and developmental biology have introduced a new era marked by the generation of in vitro models that recapitulate early mammalian development, providing unprecedented ...

Scientists in the Brivanlou lab used light-inducible gene expression (yellow circle) and embryo models to demonstrate that, at the start of gastrulation, body-axis formation requires an interplay ...

Embryonic stem cells (ESCs) are found in the inner cell mass of the human blastocyst, an early stage of the developing embryo lasting from the 4 th to 7 th day after fertilization. In normal embryonic ...

A new discovery by researchers challenges our current understanding of gastrulation, the most important stage of early embryonic development. When the zygote, or the fertilised egg, starts to develop, ...

Embryonic development, also known as embryogenesis, is a cornerstone in understanding the origins of life. But studying this marvel of intricate and layered biological processes in people faces ...

For several years, researchers studied human embryonic stem cells (ESCs) to understand the unique features of these pluripotent cells, but on their own, they poorly resembled the complex structures ...

Research improves upon a popular experimental model of mammal development and in doing so, reveals more of the inner workings of a critical period during the formation of an embryo. Research from Ph.D ...