In three back-to-back papers and five pages of the April 25, 1953, issue of Nature, seven authors laid out the evidence and interpretation that established the double helical structure of DNA. As ever ...

Large-scale annotation efforts over the past two decades have identified regulatory regions and networks through functional genomics and evolutionary analyses. The challenge now will be to incorporate ...

Sequence-based deep learning has advanced genome interpretation, yet most models remain task-specific and rely on retraining, limiting scalability across biological contexts. Here we present SUCCEED, ...