The expression of genes has to be carefully regulated in cells; active genes give cells their identity and ability to function. Epigenetic features are just one way that cells control gene expression, ...

Immunotherapy is one of the pillars in the fight against cancer and aims to enable the body's own immune system to fight a tumor. A recent study now shows that removing certain enzymes that regulate ...

Post-traumatic osteoarthritis often affects younger, active individuals and progresses quickly following ligament or cartilage injury. Chondrocytes, the sole cell type in articular cartilage, survive ...

The genome is a fascinating place, consisting of complex loops of DNA that are transcribed into RNA, which is translated into protein. However, DNA expression is controlled by factors beyond the ...

Cellular findings show Telomir-Zn modulates intracellular metal balance linked to oxidative stress, mitochondrial ...

Researchers developed e2MPRA, a high-throughput technique that simultaneously measures cis-regulatory element activity and epigenetic state. By analyzing thousands of sequences, the method showed that ...

Post-traumatic osteoarthritis develops rapidly after joint injury, yet current treatments largely address symptoms rather ...

Flowering time determines reproductive success in perennial trees, yet the epigenetic mechanisms underlying sexual asynchrony remain poorly understood.

A single exposure to a toxic fungicide during pregnancy can increase the risk of disease for 20 subsequent generations—with inherited health problems worsening many generations after exposure. Those ...

Image credit:© Davide Normanno, French National Centre for Scientific Research (CNRS), shared under the CC BY 4.0 International license. To test their hypothesis, they turned to the fruit fly, ...