GABAergic interneurons play key roles in cortical circuits, yet little is known about their early connectivity. Here we use glutamate uncaging and a novel optogenetic strategy to track changes in the ...

Researchers have developed a technique for selectively targeting and controlling the interneurons of the cerebellar molecular layer relying on a genetically engineered mouse model that exploits a ...

A new study reveals how interneurons, dubbed 'the butterflies of the soul,' emerge and diversify in the brain. The findings may help inform the development of new classes of drugs for diseases such as ...

Researchers at the University of Virginia School of Medicine have uncovered how problems in cortical microcircuits in the brain can trigger epileptic seizures. The researchers say that targeting the ...

Researchers have successfully demonstrated how astroglia – cells that support the functioning of the brain – can be reprogrammed into cells resembling interneurons. The research, published in Science ...

One hypothesis for the death of motor neurons in amyotrophic lateral sclerosis (ALS) is that the neurons become hyperexcited, firing overtime and ultimately being poisoned by their own activity (Rao ...

An LSU Health New Orleans research study led by Siqiong June Liu, PhD, Professor of Cell Biology and Anatomy, has found that cerebellar inhibitory interneurons are essential for fear memory, a type of ...

Labeling of intraregional synapses using LCD-eGRASP in the basolateral amygdala (BLA). Engram cells (Red), Non-engram cells (White), synapses from activated inhibitory interneurons (yellow), and ...