Medical Xpress

Mapping potential pathways to motor neuron disease treatment

For the first time, researchers from the University of Queensland (UQ) have mapped out the proteins implicated in the early stages of motor neuron disease (MND). Dr. Rebecca San Gil from Associate ...
Medical Xpress

New insights into the protein-mediated motor neuron loss in amyotrophic lateral sclerosis

Our movements are controlled by multiple neural pathways that connect the brain and spinal cord. In particular, neurons in the cerebral cortex send commands to the motor neurons in the spinal cord and ...
Nature

Descending projection neurons in the primary sensorimotor cortex regulate neuropathic pain and locomotion in mice

Cortical descending modulation of sensory processing in the spinal cord has been revealed, the role of cortico-brainstem projections in sensory and motor regulation remains poorly investigated. Here, ...
Nature

Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS

Mutations in FUS and TARDBP cause amyotrophic lateral sclerosis (ALS), but the precise mechanisms of selective motor neuron degeneration remain unresolved. To address if pathomechanisms are shared ...