The NFL Week 12 schedule starts with the Buffalo Bills at Houston Texans on Thursday Night Football on Nov. 20 and concludes with the Carolina Panthers at San Francisco 49ers on Monday Night Football on Nov.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 on a 48-33 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

The New York Giants (2-9) visit the Detroit Lions (6-4) at Ford Field in Detroit for a Week 12 showdown, and USA TODAY's panel of NFL experts have locked in their picks and predictions for the action.