How oligodendrocytes use fatty acid metabolism as an energy reserve to maintain axonal function and myelin stability when glucose is scarce, offering insights into neurodegenerative disease mechanisms ...

Nerve fibers in the brain and spinal cord are wrapped in an insulating sheath known as myelin. For a long time, this barrier, ...

Oligodendrocytes with different morphological features work together to support precise binaural integration for sound localization in the chick brainstem auditory circuit.

The central nervous system (CNS) critically depends on the integrity of oligodendrocytes, specialised glial cells responsible for the formation and maintenance of myelin sheaths. Myelin not only ...

Abnormal oligodendrocyte function has been postulated as a primary etiological event in schizophrenia. Oligodendrocyte lineage transcription factor 2 (OLIG2) encodes a transcription factor central to ...

Multiple sclerosis is a condition whereby the immune system attacks and destroys myelin – the protective coating of nerve fibers – which triggers movement problems characteristic of the disease. Now, ...

Until recently, oligodendrocytes were primarily thought to be a kind of cellular insulating tape that accelerates the transmission of electrical signals in the brain. A study now shows that they are ...

The results of preclinical studies headed by investigators at the UK Dementia Research Institute at University College London, and colleagues, suggest that non-neuronal brain cells called ...

Nursemaid oligodendrocytes care for neuronal axons not only by wrapping them in insulating myelin, but also by feeding them lactate, according to two papers in Nature. This is a fairly newfound ...

A new study shows metformin enhances myelin repair in human-based models by tuning mitochondrial metabolism, offering hope for multiple sclerosis treatment. Study: Metformin alters ...