Nature

Differentiated Thyroid Carcinoma That Express Sodium-Iodide Symporter Have a Lower Risk of Recurrence for Children and Adolescents

The NIS is a membrane-bound glycoprotein cotransporter expressed by thyroid, salivary, gastric, mammary, and extraocular tissues (1–4). NIS is essential for the uptake of iodide and thyroid hormone ...
Nature

Enhanced iodide transport after transfer of the human sodium iodide symporter gene is associated with lack of retention and low absorbed dose

Immunocytochemistry using two different clones of anti-NIS antibodies (BrA 6-1 and BrA 10-11) revealed a strong red fluorescence (Cy3) on the cell surface of hNIS expressing AT1 cells, whereas ...
Phys.org

Blocking iodide transport by inhibiting the sodium iodide symporter

(Phys.org)—Iodide entrapment in the thyroid gland is essential, and plays a key role in dysfunctions such as thyroid and breast cancers, thyroiditis, Graves–Basedow disease, and Hashimoto's disease.
The New England Journal of Medicine

Reduce, Recycle, Reuse — Iodotyrosine Deiodinase in Thyroid Iodide Metabolism

Thyroid hormones are essential for normal brain development, growth, and metabolism. Their synthesis is dependent on a normally developed thyroid gland, an adequate nutritional intake of iodide, and a ...