Chris Flexen gave up a home run to Mike Tauchman as the Northsiders dropped a Friday contest to their Chicago counterparts.

Since the White Sox won the last game on August 15, 2023, the Cubs have beat them eight straight games. There was one win in 2023, then the Cubs won all four in August of 2024. Earlier this season, the Cubs swept the White Sox, outscoring them 26-8.

The Chicago Cubs (60-42) visit the South Side of Chicago to face the Chicago White Sox (37-66) Friday in the first game of a 3-game interleague series. First pitch from Rate Field is at 7:40 p.m. ET. Let's analyze BetMGM Sportsbook's MLB odds around the Cubs vs. White Sox odds and make our expert MLB picks and predictions for the best bets.

All-Star Pete Crow-Armstrong hit his 26th homer, one of five solo shots for the Cubs to back seven sharp innings by Shota Imanaga, and Chicago beat the Boston Red Sox 6-0.

PHILADELPHIA — Instant reactions as the Red Sox (55-49) fight and claw to a landmark, sweep-avoiding 9-8 victory in a back-and-forth, dramatic game in which Carlos Narváez won it with a two-run homer in the top of the 11th inning:

Chicago White Sox's Jonathan Cannon delivers a pitch in the first inning against the Boston Red Sox on Monday, April 21, 2025, in Boston. (AP Photo/Steven Senne)

BOTTOM LINE: The Chicago Cubs lead 1-0 in a three-game series with the Boston Red Sox. Chicago is 31-16 at home and 58-39 overall. The Cubs have a 44-7 record in games when they out-hit their opponents.

The Boston Red Sox visit the Chicago Cubs Saturday evening for the second game of their 3-game series at Wrigley Field in Chicago.

The Jekyll-and-Hyde offense that has plagued the Red Sox all season resurfaced after the break. Boston’s offense still ranks among league leaders, partly due to 16 games in which the Red Sox have scored 10 or more runs.

The Cubs wasted a sharp performance by Cade Horton, who pitched 5 2/3 innings of two-hit ball. The Cubs had won five of six.