According to head coach Kyle Shanahan, running back Christian McCaffrey suffered a potentially season-ending PCL injury in their 35–10 loss against the Buffalo Bills.

Christian McCaffrey's 2024/25 NFL season could be over in a devastating blow to the San Francisco 49ers after the 28-year-old ...

The swagger is officially gone from this season's 49ers after another miserable outing in a 35-10 loss in Buffalo.

In a disappointing season a team typically reaches a point of no return, a realization that, “we have met the enemy, and it ...

The 49ers season is still trending down and now they're searching for answers on if they can get back on track.

The 49ers were among the preseason favorites to win the Super Bowl, but now they look like long shots to make the playoffs.

The weather outside was frightful at Highmark Stadium in Orchard Park, New York on Sunday night, but the way the San ...

After Sunday night's humbling loss in snowy Buffalo, it's time for Kyle Shanahan and John Lynch to start shutting ...

The San Francisco 49ers' losses to the Green Bay Packers and Buffalo Bills mark the worst two-game stretch by a defending ...

San Francisco 49ers running back Christian McCaffrey could be done for the season after just four games. As head coach Kyle ...

Buffalo was a perfect 4-for-4 in the red zone. A big factor in the Bills' success was their run game. RB James Cook had 14 ...