The Niners have three MVP-caliber players on offense. All have failed to live up to that standard this season.

We could be looking at a Winter Wonderland in Buffalo when the Bills host the 49ers in a December affair with playoff ...

Meanwhile, the 5-6 49ers are dealing with massive injury struggles. All-Pro left tackle Trent Williams, Defensive Player of ...

Purdy is officially listed as questionable for the game, though coach Kyle Shanahan said the plan is for him to start on ...

Head coach Kyle Shanahan recapped the team's 35-10 loss to the Buffalo Bills, evaluated the 49ers performance on "Sunday ...

Defensively, two of the 49ers’ best players this season are out and will not travel as defensive end Nick Bosa (obliques, ...

The San Francisco 49ers have released their final injury report ahead of their Week 13 bout with the Buffalo Bills.

The 49ers won't have their best pass rusher when they face the Bills on Sunday. Nick Bosa will miss his second game in a row with an oblique injury ...

Head coach Kyle Shanahan shared the final injury report on QB Brock Purdy, DL Nick Bosa and others and discussed the team's ...

First comes Brock Purdy, the team's star quarterback, who missed Week 12 with a right shoulder. While Purdy is still ...

San Francisco 49ers quarterback Brock Purdy appears to be making strides in his recovery from a shoulder injury. During the ...

San Francisco 49ers defensive end Nick Bosa (hip) and offensive tackle Trent Williams (ankle) will not suit up in Week 13 to face the Buffalo Bills, according to Eric Branch of the San Francisco ...