Running back McCaffrey has been both one of the reasons for and one of the victims of San Francisco’s poor form in 2024.

The San Francisco 49ers have had to deal with multiple running back injuries this season and another went down in Week 18 against the Arizona Cardinals. Rookie Isaac Guerendo went down on the fourth ...

The 49ers injury woes continue at running back after Isaac Guerendo was carted off the field in the 1st quarter.

The Giants let Saquon Barkley leave the team in free agency. He signed with the Eagles and became one of just nine RBs to eclipse 2,000 rushing yards.

It didn't take long for the final game of a San Francisco 49ers season defined by injury adversity to be marred by yet ...

Kyler Murray threw for 242 yards and four touchdowns, two to Greg Dortch, and the Arizona Cardinals beat the injury-depleted San Francisco 49ers 47-24.

What's the San Francisco 49ers vs Arizona Cardinals score? Follow our live updates for latest news, highlights, analysis from NFL Week 18 game.

The San Francisco 49ers concluded their 2024 season on the road against the Arizona Cardinals. Among the long list of of injured players not suiting up for the season finale was QB1 Brock Purdy, who ...

Murray’s blooming connection with Harrison and tight end Trey McBride gives the Cards something to look forward to next fall, ...