The San Francisco 49ers on Wednesday began their week of practice as they gear up for what amounts to a season-ending stretch ...

HC Kyle Shanahan provided updates about LB Dre Greenlaw, S Talanoa Hufanga, and why he’s excited about Isaac Guerendo’s ...

A spate of injuries has derailed the 49ers' Super Bowl hopes his season, but the bigger question is if their title window has ...

It’s back to the grind for a weary 49ers team attempting to hold onto their rapidly waning playoff dreams. They’ll face a ...

Recapping the latest injury updates and roster moves following "SNF" vs. the Bills including news on RB Christian McCaffrey, ...

Isaac Guerendo didn’t start in college until his final game.. He starts at running back for the 49ers Sunday against Chicago.

Cornerback Deommodore Lenoir (knee), linebacker Dre Greenlaw (Achilles) and safety Talanoa Hufanga (wrist) were limited.

Head coach Kyle Shanahan reflected on the team's performance against the Bills, previewed the upcoming Week 14 matchup ...

With just over a month left in the regular season, the NFL Power Rankings are largely about teams at the top shuffling with ...

The 49ers have had more than their share of bad injury news this season, but they got some good injury news Wednesday. Safety ...

Should Saquon Barkley be considered the Eagles' most important addition of the past offseason? Will the Falcons' decline ...