McCaffrey left Sunday’s blowout loss in Buffalo with a knee injury, and Kyle Shanahan was quick to rule him out.

The San Francisco 49ers have released the list of inactive players for their Week 13 matchup against the Buffalo Bills. These ...

The loss of starter J.K. Dobbins, IR-ed with a knee, showed right away. Hassan Haskins lost a fumble on his own 27, leading ...

We could be looking at a Winter Wonderland in Buffalo when the Bills host the 49ers in a December affair with playoff ...

Purdy is officially listed as questionable for the game, though coach Kyle Shanahan said the plan is for him to start on ...

Head coach Kyle Shanahan recapped the team's 35-10 loss to the Buffalo Bills, evaluated the 49ers performance on "Sunday ...

San Francisco 49ers TE George Kittle, LB Fred Warner and QB Brock Purdy outlined the team's performance on "SNF" against the Buffalo Bills.

Three things I’m pondering as the Bills return from their bye for the stretch run… Mila-No More Waiting Matt Milano is ...

Purdy's status would have a massive impact on the outcome of the game. Backup quarterback Brandon Allen, who started in Purdy ...

Defensively, two of the 49ers’ best players this season are out and will not travel as defensive end Nick Bosa (obliques, ...

The San Francisco 49ers have released their final injury report ahead of their Week 13 bout with the Buffalo Bills.

First comes Brock Purdy, the team's star quarterback, who missed Week 12 with a right shoulder. While Purdy is still ...