EMBO Press11h
Dimerization of GAS2 mediates crosslinking of microtubules and F-actin
GAS2 is a cytoskeletal regulator that interacts with both F-actin and microtubules. Here, cryo-EM structures of GAS2 domains ...
EMBO Press8d
PARP7 as a new target for activating anti-tumor immunity in cancer
PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...
EMBO Press6d
Beyond mitotic arrest: the diverse effects of microtubule-targeting drugs on tumor vasculature
For decades microtubule-targeting agents (MTAs) have been a cornerstone of cancer treatment regimens and continue to be heavily employed as backbone chemotherapy in combination with new targeted ...
EMBO Press12d
A new hybrid post-translational modification—have you lost your (MARUb)les?
Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...
The EMBO Journal4d
Syndecans and glycosaminoglycans influence B-cell development and activation
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Syndecans (SDCs) are ...
The EMBO Journal7d
Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Immune memory plays a critical role in the ...
The EMBO Journal5d
TFE3 fusions drive oxidative metabolism and ferroptosis resistance in translocation renal cell carcinoma
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The oncogenic mechanisms by which TFE3 fusion ...
The EMBO Journal4d
HDAC6 deacetylates ENKD1 to regulate mitotic spindle behavior and corneal epithelial homeostasis
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Corneal diseases can cause severe visual ...
The EMBO Journal6d
Mitochondrial fatty acid oxidation regulates adult muscle stem cell function through modulating metabolic flux and protein acetylation
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The bioenergetic requirements of muscle stem ...
The EMBO Journal5d
Praja2 controls P-body assembly and translation in glioblastoma by non-proteolytic ubiquitylation of DDX6
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Glioblastoma multiforme (GBM) is the most ...
The EMBO Journal5d
Soluble CD27 differentially predicts resistance to anti-PD1 alone but not with anti-CTLA-4 in melanoma
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Metastatic melanoma can be treated with ...