The JAK/STAT pathway
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The JAK/STAT pathway
The JAK/STAT pathway begins with the activation of a membrane bound cytokine receptor by interferon or another cytokine. The activated receptor recruits and activates intracellular tyrosine kinases of the JAK family. Active JAKs phosphorylate STAT proteins, which then dimerize, enter the nucleus and activate gene transcription. Genes activated ...
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